Covid-19: Overview

COVID-19: Global Effort to Stop a Global Virus

Allarity Therapeutics is a dynamic workplace working to make the promise of precision cancer medicine a reality for patients worldwide.

In April 2020, Allarity Therapeutics entered into an agreement with the Pathogen and Microbiome Institute at Northern Arizona University (NAU) to test the antiviral activity of Stenoparib (2X-121) against COVID-19. Read the press release here

Pivoting to Help the Global Crisis; Advancing Stenoparib Into Human Clinical Trials as a Potential Therapy for COVID-19.

Our team, like many others in our industry, has been watching closely the developments in the global effort to stem the COVID-19 pandemic. Noting in a scientific publication that another PARP inhibitor, mefuparib (CVL218), had shown promising antiviral activity against the virus that causes COVID-19, Allarity quickly pivoted and began evaluating  stenoparib, our dual PARP and Tankyrase Inhibitor in Phase 2 development for ovarian cancer, as a potential treatment for COVID-19.

We are working with NUA, a leading U.S. infectious disease test center, on a preclinical program to assess the ability of stenoparib to block the infection of cells and replication of coronavirus. In a series of preclinical studies, stenoparib showed inhibitory activity against coronavirus in LLC-MK2 cells as a single agent. In addition, stenoparib in combination with remdesivir was active in inhibiting SARS-Cov-2, the virus that causes COVID-19, in VERO E6 cells. The concentration of stenoparib required for virus inhibition was lower in the combination study than in the single agent study. 

The two drugs target the virus through unique but different mechanisms of action. Remdesivir blocks the RNA replication enzyme, while stenoparib, as an inhibitor of PARP1/PARP2 (Poly ADP-Ribose Polymerases) and tankyrase 1 and 2 inhibits virus assembly and inhibits the negative effects of virus infection on the human body such as cytokine storm and necrosis.

The preclinical testing has been conducted at the Pathogen and Microbiome Institute at Northern Arizona University (NAU). NAU built the Pathogen and Microbiome Institute labs in 2008 to enable researchers to handle dangerous pathogens, including research on diseases such as West Nile virus and Zika virus.

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At Allarity Therapeutics, we are defining a bright future for patients in a new paradigm of precision cancer treatments. Our mission is to bring clarity to personalized oncology medicines, marrying innovative therapies and superior companion diagnostics, to help fully realize the promise of personalized cancer care.

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